[Liver enzymes in the guinea pig after chronic oral administration of elemental sulfur]

The guinea-pigs protractedly exposed per os to sulphur in a daily dose of 200 mg/kg body weight show, depending on the exposure period, in their livers, varied intensity of histochemical enzymatic reactions and different ALAT activity in blood serum. After 30 days' exposure to sulphur the intensity of enzymatic reactions is almost similar to that in controls or somewhat lower, whereas in the blood serum there is an increase in the activity of alanine aminotransferase. After the lapse of 90, 180 and 270 days of exposure, the animals' livers are observed to disclose a rise in reactions to the activity of mitochondrial, lysosomal enzymes as well as G-6-P-ase, esterase AS and ATP-ase, whereas in blood serum AspAT and ALAT reveal no difference in the activity level with regard to the control value.