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A cDNA clone containing the entire coding sequence of a mouse H-2Kd histocompatibility antigen
Nucleic Acids Research
|March 11, 1983
Summary
Researchers isolated a cDNA clone for the H-2K(d) mouse histocompatibility antigen. The clone
Area of Science:
- Immunogenetics
- Molecular Biology
- Biochemistry
Background:
- Histocompatibility antigens, such as H-2K(d), play critical roles in immune responses.
- Understanding the genetic basis of these antigens is crucial for immunology and transplantation research.
Purpose of the Study:
- To isolate and characterize a cDNA clone encoding the H-2K(d) mouse histocompatibility antigen.
- To analyze the sequence and structural features of the H-2K(d) gene.
Main Methods:
- cDNA library screening
- DNA sequencing
- Sequence analysis
Main Results:
- Isolation of a 1560 bp cDNA clone containing the complete coding and 3' untranslated regions of the H-2K(d) antigen.
- Detailed sequence and feature analysis of the H-2K(d) cDNA.
- Identification of unique DNA sequence properties associated with the H-2K(d) antigen.
Conclusions:
- The isolated cDNA clone provides a valuable tool for studying the H-2K(d) antigen.
- The unique sequence features suggest novel regulatory mechanisms or functional properties of the H-2K(d) gene.
