Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

HLA and trophoblastic disease.

H Y Law

    Annals of the Academy of Medicine, Singapore
    |October 1, 1982
    PubMed
    Summary

    Human Leukocyte Antigen (HLA) compatibility does not influence trophoblastic disease susceptibility or progression. Tumour cells likely express minimal HLA antigens, suggesting they play a minor role in these conditions.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population.

    Breast cancer research and treatment·2012
    Same author

    Meteorological factors and aneurysmal subarachnoid haemorrhage in Hong Kong.

    Hong Kong medical journal = Xianggang yi xue za zhi·2009
    Same author

    Genetic analysis of SCA2, 3 and 17 in idiopathic Parkinson's disease.

    Neuroscience letters·2006
    Same author

    Expanded FMR1 alleles are rare in idiopathic Parkinson's disease.

    Neurogenetics·2005
    Same author

    SMN1 deletions among singaporean patients with spinal muscular atrophy.

    Annals of the Academy of Medicine, Singapore·2005
    Same author

    Fragile X premutation alleles in SCA, ET, and parkinsonism in an Asian cohort.

    Neurology·2004

    Area of Science:

    • Immunogenetics
    • Reproductive Immunology
    • Oncology

    Background:

    • Trophoblastic diseases encompass a spectrum of pregnancy-related tumours.
    • The role of Human Leukocyte Antigen (HLA) expression in trophoblastic disease pathogenesis is not fully understood.
    • Previous studies have yielded conflicting results regarding HLA and trophoblastic disease.

    Purpose of the Study:

    • To investigate the association between Human Leukocyte Antigen (HLA) antigens and the susceptibility to trophoblastic diseases.
    • To evaluate the role of HLA compatibility between patients, their partners, and tumours in disease progression.
    • To discuss the expression patterns of HLA antigens on normal and abnormal trophoblasts.

    Main Methods:

    • Analysis of HLA antigen compatibility in patient-husband and patient-tumour pairings.
    • Review of existing evidence on HLA expression in trophoblastic tissues.
    • Comparative analysis of HLA expression on normal versus malignant trophoblasts.

    Main Results:

    • No significant association was found between HLA antigen compatibility and the susceptibility to trophoblastic diseases.
    • Compatibility studies suggest HLA plays a limited role in disease susceptibility and tumour progression.
    • Evidence indicates that tumour cells likely exhibit low expression of HLA antigens on their surface.

    Conclusions:

    • Human Leukocyte Antigen (HLA) system does not appear to be a major factor in the susceptibility or progression of trophoblastic diseases.
    • The limited expression of HLA antigens on tumour cells suggests immune evasion mechanisms.
    • Further research is warranted to fully elucidate the complex interactions between trophoblasts and the maternal immune system.

    Related Experiment Videos