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Related Experiment Videos

Terbutaline serum concentrations related to different lung function parameters and beta-receptor function.

W van den Berg, J G Leferink, W Tabingh Suermondt

    International Journal of Clinical Pharmacology, Therapy, and Toxicology
    |January 1, 1983
    PubMed
    Summary

    Terbutaline effectively improved lung function in asthmatics by increasing cyclic adenosine monophosphate (cAMP) levels. However, predicting individual lung function improvement based on serum terbutaline concentration was not possible.

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    Area of Science:

    • Pharmacology
    • Pulmonary Medicine
    • Biochemistry

    Background:

    • Asthma management often involves beta-adrenergic agonists.
    • Understanding the relationship between drug concentration and therapeutic effect is crucial for optimizing asthma treatment.
    • Terbutaline is a commonly used bronchodilator.

    Purpose of the Study:

    • To correlate serum terbutaline concentrations with changes in lung function and plasma cyclic adenosine monophosphate (cAMP) levels in asthmatic and normal subjects.
    • To investigate the dose-response relationship and interindividual variability of terbutaline's effects.
    • To explore potential sites of beta-adrenergic defects in asthma.

    Main Methods:

    • Eight asthmatic and six normal subjects received subcutaneous terbutaline (0.5 mg), oral terbutaline (5 mg), or placebo.

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  • Serum terbutaline concentrations, plasma cAMP levels, and lung function parameters (FEV1, MEF50%, Gaw, sGaw) were measured.
  • Statistical correlations were performed to analyze the relationships between variables.

    • Main Results:

    • Serum terbutaline and plasma cAMP levels correlated closely in both groups.
    • Asthmatics showed significant improvements in lung function (FEV1, MEF50%, Gaw, sGaw) post-terbutaline, while normals did not.
    • FEV1 improvement correlated linearly with serum terbutaline concentration (1.6-6 ng/ml), with maximal effect at 30-60 min (subcutaneous) and 2-4 h (oral).
    • Interindividual variance in serum terbutaline was low, but predicting lung function improvement was not feasible based on concentration alone.

    Conclusions:

    • Terbutaline effectively improves lung function in asthmatics, correlating with increased cAMP levels.
    • Similar cAMP responses in normals and asthmatics suggest a potential beta-adrenergic defect localized within lung tissue in asthmatics.
    • While terbutaline shows predictable pharmacokinetics, individual responses in lung function remain variable.