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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

[Structural-functional organization of hemostatic clots]

V K Kozlov, A K Chepurov

    Biulleten' Eksperimental'Noi Biologii I Meditsiny
    |February 1, 1978
    PubMed

    The studies were carried out to verify the hypothesis on the structural-functional organization of the hemostatic clot. For this purpose the influence of the platelets and their aggregate condition on the mechanical properties of the clot was investigated. Redistribution of platelets into aggregated, caused by addition of ADP and mixing, led to the inhibition of the clot retraction. This was reflected in the form of reduction of am on the thromboelastogram. Simultaneous recording of thrombloelastogram, coagulbbogram, and platelet degranulation demonstrated that processes of viscid metamorphosis of platelets and fibrin filaments sedimentation were followed by active clot contraction. The clot is a fibrin-platelet structure whose nodes contain blood platelets, and cells--the rest blood elements. The clot retraction takes place due to contractile properties of platelets.

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