[Analgesia induced by creation of a generator of excitation in the midbrain]

Experiments were conducted on albino rats. An excitation generator in the dorsal nucleus of the midbrain raphe was created by means of tetanus toxin. Formation of the excitation generator in this nucleus led to the development of general analgesia, expressed against physiological pain (nociceptive stimulation) and the central pathological pain (pain syndrome of spinal origin). A conclusion was drawn that prolonged analgesia occurring in activation of certain structures of the brain was caused by the origination in them of excitation generators causing prolonged activation of these structures.