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Related Experiment Videos

Proton NMR imaging in experimental ischemic infarction.

F S Buonanno, I L Pykett, T J Brady

    Stroke
    |March 1, 1983
    PubMed
    Summary

    Nuclear magnetic resonance (NMR) imaging detects early changes in proton relaxation times (T1 and T2) in experimental stroke. These NMR imaging alterations appear as soon as two hours after carotid artery ligation, indicating early ischemic infarction.

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    Area of Science:

    • Biomedical Imaging
    • Neuroscience
    • Radiology

    Background:

    • Proton nuclear magnetic resonance (NMR) imaging visualizes proton distribution and concentration, influenced by T1 and T2 relaxation times.
    • Experimental ischemic infarction models are crucial for understanding stroke pathophysiology and developing diagnostic tools.

    Purpose of the Study:

    • To investigate the utility of NMR imaging, specifically the steady-state-free-precession (SSFP) technique, in detecting early signs of ischemic infarction.
    • To correlate NMR imaging findings with pathological evidence of infarction and compare them with conventional NMR techniques.

    Main Methods:

    • Serial coronal NMR images were acquired using the SSFP technique in laboratory animals with experimentally induced ischemic infarction.
    • In vitro measurements of T1 and T2 relaxation times were performed on gerbil brain tissue from normal, infarcted, and recovered groups.

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  • SSFP images were compared to inversion-recovery NMR images in a human patient with cerebral infarction.

    • Main Results:

    • NMR image changes indicative of ischemic infarction were observable as early as 2 hours post-carotid artery ligation.
    • Infarcted hemispheres showed significantly prolonged T1 (1.47 ± 0.12 sec) and T2 (76.0 ± 9.0 msec) relaxation times compared to contralateral hemispheres.
    • These prolonged relaxation times were also significantly different from those in normal gerbils or those clinically recovered after ligation.

    Conclusions:

    • NMR imaging parameters, specifically T1 and T2 relaxation times, change measurably during ischemic infarction.
    • The SSFP NMR imaging technique can detect these changes early, within 2 hours of arterial ligation, offering potential for early stroke diagnosis.