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Summary
Cerebrospinal fluid enzyme levels differ significantly between cortical and lacunar strokes. Cortical strokes show elevated creatine kinase (CK), lactate dehydrogenase (LDH), and glutamate oxaloacetate transaminase (GOT), unlike lacunar strokes.
Area of Science:
- Neurology
- Biochemistry
Background:
- Cerebrospinal fluid (CSF) enzyme levels in acute stroke patients have been previously studied.
- The diagnostic utility of specific enzyme elevations in differentiating stroke types remains an area of interest.
Purpose of the Study:
- To investigate and compare cerebrospinal fluid (CSF) enzyme levels (creatine kinase (CK), lactate dehydrogenase (LDH), glutamate oxaloacetate transaminase (GOT), and angiotensin converting enzyme (ACE)) in patients with acute lacunar versus cortical strokes.
- To explore potential correlations between enzyme levels, infarct characteristics (site, size), and stroke type.
Main Methods:
- Analysis of CSF enzyme levels in 40 acute stroke patients (20 lacunar, 20 cortical).
- Enzymes measured included CK, LDH, GOT, and ACE.
- Correlation with CT scan findings for infarct characteristics in cortical strokes.
Main Results:
- Significant elevations in CK, GOT, or LDH were observed in 80% of cortical stroke cases.
- Lacunar strokes showed no elevation in CK, GOT, or ACE, with only slight LDH elevation.
- A correlation was found between infarct site/size on CT scan and enzyme levels within the cortical stroke group.
Conclusions:
- CSF enzyme profiles differ notably between cortical and lacunar strokes.
- CSF enzyme analysis may aid in distinguishing between cortical and lacunar stroke types.
- Accurate differentiation is crucial for patient management, clinical trial enrollment, and syndrome characterization.