Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute panautonomic neuropathy.

P A Low, P J Dyck, E H Lambert

    Annals of Neurology
    |April 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Generation of a multi-antigen-directed immune response for durable control of acute lymphoblastic leukemia.

    Leukemia·2018
    Same author

    Generation of a multi-antigen-directed immune response for durable control of acute lymphoblastic leukemia.

    Leukemia·2017
    Same author

    Improved anti-leukemia activities of adoptively transferred T cells expressing bispecific T-cell engager in mice.

    Blood cancer journal·2016
    Same author

    Inhibition of precursor B-cell malignancy progression by toll-like receptor ligand-induced immune responses.

    Leukemia·2016
    Same author

    Correlation of Descriptive Analysis and Instrumental Puncture Testing of Watermelon Cultivars.

    Journal of food science·2016
    Same author

    Microscopic quantification of cell integrity in raw and processed onion parenchyma cells.

    Journal of food science·2011

    Acute panautonomic neuropathy involves severe sympathetic and parasympathetic dysfunction. Nerve biopsies reveal fiber loss in some cases, suggesting a spectrum of autonomic and somatic involvement.

    Area of Science:

    • Neurology
    • Autonomic Neuroscience

    Background:

    • Acute panautonomic neuropathy is characterized by sudden, severe impairment of both sympathetic and parasympathetic nervous system functions.
    • Understanding the underlying pathology is crucial for diagnosis and management of this rare condition.

    Observation:

    • Two patients presented with acute panautonomic neuropathy, exhibiting profound autonomic dysfunction.
    • Patient 1 showed nerve biopsy evidence of unmyelinated and small myelinated fiber loss, indicative of a postganglionic lesion.
    • Patient 2 had no significant findings on nerve biopsy despite similar clinical presentation.

    Findings:

    • Autonomic testing in Patient 1 suggested a postganglionic lesion.
    • Specific findings in Patient 1 included selective loss of small myelinated and unmyelinated nerve fibers, absent C potential, and unmeasurable dopamine-beta-hydroxylase activity.

    Related Experiment Videos

  • Nerve biopsy in Patient 2 revealed no definitive abnormalities.

    • Implications:

    • Acute panautonomic neuropathies may represent a spectrum of disease with varying degrees of nerve fiber involvement.
    • These findings highlight the heterogeneity in the pathological presentation of acute panautonomic neuropathy.
    • Further research is needed to elucidate the full spectrum and underlying mechanisms of acute panautonomic neuropathies.