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Related Experiment Videos

Ketoconazole.

A L Hume, T M Kerkering

    Drug Intelligence & Clinical Pharmacy
    |March 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Ketoconazole is approved for many fungal infections but lacks extensive peer-reviewed data. Further clinical trials are needed to confirm its effectiveness and optimal dosage for antifungal therapy.

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    Area of Science:

    • Mycology
    • Pharmacology
    • Infectious Diseases

    Background:

    • Fungal infections present treatment challenges due to drug resistance and toxicity.
    • Ketoconazole, an oral imidazole antifungal, is FDA-approved for various fungal infections.
    • Limited peer-reviewed literature exists on ketoconazole's efficacy for several approved indications.

    Purpose of the Study:

    • To review the current status of ketoconazole in treating fungal infections.
    • To highlight the need for further clinical evidence regarding ketoconazole's effectiveness and safety.
    • To discuss the recommended dosage and duration of ketoconazole therapy.

    Main Methods:

    • Literature review of existing studies on ketoconazole.
    • Analysis of reported adverse reactions and preliminary findings on steroidogenesis.

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  • Examination of FDA-approved indications for ketoconazole.

    • Main Results:

    • Gastrointestinal side effects are the most common adverse reactions.
    • Preliminary data suggest higher ketoconazole doses may inhibit adrenal steroidogenesis.
    • Current recommendations are 200-400 mg/day, with undefined therapy duration.

    Conclusions:

    • Ketoconazole's effectiveness for several approved fungal infections requires more robust clinical validation.
    • The potential impact on adrenal steroidogenesis warrants further investigation.
    • Until comprehensive clinical trials are completed, ketoconazole use should be judiciously limited.