Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Bacterial cell wall components decrease the number of guinea-pig lung beta-adrenoceptors.

A J Schreurs, J Verhoef, F P Nijkamp

European Journal of Pharmacology

|January 28, 1983

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A low vitamin A status increases the susceptibility to cigarette smoke-induced lung emphysema in C57BL/6J mice.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2011

Same author

A whey-based glutathione-enhancing diet decreases allergen-induced airway contraction in a guinea-pig model of asthma.

The British journal of nutrition·2011

Same author

Glutathione prevents the early asthmatic reaction and airway hyperresponsiveness in guinea pigs.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2010

Same author

Cigarette smoke induces CXCL8 production by human neutrophils via activation of TLR9 receptor.

The European respiratory journal·2009

Same author

Oral treatment with probiotics reduces allergic symptoms in ovalbumin-sensitized mice: a bacterial strain comparative study.

International archives of allergy and immunology·2009

Same author

Cigarette smoke suppresses in vitro allergic activation of mouse mast cells.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2009

Same journal

Astaxanthin inhibits platelet-mediated thrombosis via suppression of bidirectional αIIbβ3 signaling.

European journal of pharmacology·2026

Same journal

Repurposing of alogliptin to mitigate experimentally-induced ulcerative colitis and its associated pulmonary injury in rats through regulating inflammatory, necroptotic, and ER stress pathways.

European journal of pharmacology·2026

Same journal

Erianin ameliorates liver fibrosis through the PRDX3/NLRX1 axis.

European journal of pharmacology·2026

Same journal

4-Octyl itaconate attenuates renal calculi formation by inhibiting ferroptosis and oxidative stress via the Nrf2-HO-1/SLC7A11 axis.

European journal of pharmacology·2026

Same journal

VER155008 rescues cognitive impairment in P301S tauopathy mice by promoting HSPA8-mediated lipophagy.

European journal of pharmacology·2026

Same journal

Okanin alleviates osteoarthritis by suppressing oxidative stress and pyroptosis via Nrf2/HO-1 activation.

European journal of pharmacology·2026

See all related articles

Certain respiratory infections decrease beta-adrenoceptors in the lungs, potentially worsening chronic asthmatic bronchitis. Bacterial endotoxins, particularly their O-antigenic side chains, appear responsible for this reduction.

Area of Science:

Pulmonary Medicine
Microbiology
Pharmacology

Background:

Chronic asthmatic bronchitis progression is linked to deeper respiratory airway infections.
Beta-adrenoceptors play a crucial role in regulating airway function.

Purpose of the Study:

To investigate the impact of various microorganisms on beta-adrenoceptor numbers in guinea-pig lung homogenates.
To identify specific microbial components responsible for changes in beta-adrenoceptor levels.

Main Methods:

Exposure of guinea-pig lung homogenates to different bacteria (Haemophilus influenzae, Streptococcus pneumoniae, Bordetella pertussis, Escherichia coli strains, Staphylococcus aureus) and influenza A virus.
Testing the effect of purified endotoxin and its components (lipid, polysaccharide) from Escherichia coli O111B4 on beta-adrenoceptor numbers.

Related Experiment Videos

Main Results:

Haemophilus influenzae, Streptococcus pneumoniae, Bordetella pertussis, and Escherichia coli O111B4 significantly decreased beta-adrenoceptor numbers by ~20%.
Staphylococcus aureus, influenza A virus, and Escherichia coli J5 did not affect beta-adrenoceptor levels.
Purified endotoxin from E. coli O111B4 reduced beta-adrenoceptors, but E. coli J5-LPS and isolated lipid/polysaccharide components did not.

Conclusions:

Gram-negative bacterial endotoxins, specifically their O-antigenic polysaccharides, may reduce beta-adrenoceptor numbers.
This reduction in beta-adrenoceptors could contribute to the pathogenesis of chronic asthmatic bronchitis.
Intact endotoxin structure is essential for this effect.