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Updated: Aug 19, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Effect of pentagastrin on adrenocorticotropin hormone and thyroid-stimulating hormone release in normal subjects
Abstract:
The possible role of gastrin on TSH, ACTH and cortisol secretion was evaluated by intravenous administration of pentagastrin, the carboxyl-terminal tetrapeptide of gastrin (0.5 microgram/kg b.w.) into 12 healthy subjects. Pentagastrin produced a significant rise in plasma ACTH and cortisol levels but did not alter TSH basal release. These preliminary results suggest that gastrin can influence basal activity of ACTH-cortisol axis. However, further investigation is required to determine its physiological role and mechanisms of action.
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