Oncocytic hepatocellular tumour

A case of hepatocellular carcinoma in a non-cirrhotic liver of a 51-year-old female is described. The macroscopic appearance is of a well circumscribed tumour measuring 20 X 10 cm with a central fibrous scar. Histologically, the tumour is an unusual variant of epithelial liver cell tumour characterized by polygonal cells set in a fibrous stroma and showing oncocytic change. Electron microscopy confirms the oncocytic features. Oncocytic change in liver cell and other tumours is discussed.