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Renal disease profoundly alters cortical interstitial cell function.

B B Davis, D Thomasson, T V Zenser

    Kidney International
    |March 1, 1983
    PubMed
    Summary
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    Hydronephrosis alters kidney interstitial cells, increasing their growth and prostaglandin E2 production in response to bradykinin. These functional changes in hydronephrotic kidneys may explain altered renal function.

    Area of Science:

    • Nephrology
    • Cell Biology
    • Renal Physiology

    Background:

    • Hydronephrosis is associated with altered renal function and prostaglandin synthesis.
    • The role of renal interstitial cells in hydronephrosis-induced changes is not fully understood.

    Purpose of the Study:

    • To investigate functional changes in interstitial cells from hydronephrotic kidneys.
    • To compare interstitial cells from hydronephrotic, contralateral, and normal kidneys.

    Main Methods:

    • Culture of interstitial cells from explants of unilaterally hydronephrotic, contralateral, and normal kidneys.
    • Identification of cell types (macrophages, fibroblasts).
    • Assessment of cell growth rates and prostaglandin E2 production in response to bradykinin.

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    Main Results:

    • Interstitial cells from hydronephrotic kidneys exhibited significantly faster growth rates compared to those from contralateral or normal kidneys.
    • Cells from hydronephrotic kidneys increased prostaglandin E2 production in response to bradykinin, unlike cells from normal or contralateral kidneys.
    • These findings suggest hydronephrosis induces functional alterations in cortical interstitial cells.

    Conclusions:

    • Hydronephrosis induces functional changes in renal cortical interstitial cells, including enhanced growth and bradykinin-stimulated prostaglandin E2 production.
    • These altered cellular functions may contribute to the known exaggerated prostaglandin synthesis and modulated renal function observed in hydronephrosis.
    • Cortical interstitial cells in hydronephrosis produce increased prostaglandins, impacting renal function parameters.