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Related Experiment Videos

Granulocyte proteases in human maxillary sinus secretions.

S Engquist, C Lundberg, P Venge

    Scandinavian Journal of Infectious Diseases
    |January 1, 1983
    PubMed
    Summary

    Maxillary sinusitis secretions show significant proteolytic activity, primarily from granulocytes. Enzymes like neutrophil elastase and collagenase contribute to this activity in sinus infections.

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    Area of Science:

    • Otorhinolaryngology
    • Biochemistry
    • Immunology

    Background:

    • Maxillary sinusitis is a common condition characterized by inflammation of the maxillary sinuses.
    • Retained sinus secretions can harbor various enzymes that may contribute to disease pathogenesis.
    • Understanding the enzymatic profile of these secretions is crucial for elucidating disease mechanisms.

    Purpose of the Study:

    • To investigate the proteolytic activity present in retained maxillary sinus secretions.
    • To identify the primary sources and types of enzymes responsible for this activity.

    Main Methods:

    • Analysis of retained maxillary sinus secretions from 10 consecutive patients with maxillary sinusitis.
    • Assay of proteolytic activity in all samples.
    • Enzyme characterization, focusing on granulocyte-derived proteases.

    Main Results:

    • All studied maxillary sinus secretions exhibited proteolytic activity.
    • Three purulent secretions demonstrated proteolytic activity comparable to a standard with excess pancreatic trypsin.
    • The main enzymes identified were neutrophil elastase, unspecific collagenase, and chymotrypsin-like cationic protein (CCP), all of granulocyte origin.

    Conclusions:

    • Proteolytic enzymes, predominantly from granulocytes, are present in maxillary sinus secretions during sinusitis.
    • These enzymes, including neutrophil elastase and collagenase, likely play a role in the pathophysiology of maxillary sinusitis.

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