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Correlation of membrane phosphorylation and epidermal growth factor binding to hepatic membranes isolated from
Biochimica Et Biophysica Acta
|May 5, 1983
Abstract:
The in vivo administration of L-triiodothyronine to normal adult rats produced a reduction in the number of binding sites in hepatic membranes for epidermal growth factor; hyperthyroidism had no effect on insulin binding. The decreased receptor number correlated with a decrease in epidermal growth factor-stimulated phosphorylation of isolated hepatic membrane proteins (180 and 165 kDa) with adenosine [gamma-32P]triphosphate.