Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Isolated interferon alpha-receptor complexes stabilized in vitro.

P Eid, K E Mogensen

|May 30, 1983

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Artificial intelligence-based prediction of neurocardiovascular risk score from retinal swept-source optical coherence tomography-angiography.

Scientific reports·2024

Same author

[Ultra-widefield imaging of fundus albipunctatus discovered in a 30-year-old woman seen for night blindness].

Journal francais d'ophtalmologie·2023

Same author

Women's reproductive span: a systematic scoping review.

Human reproduction open·2022

Same author

A sub-population of high proliferative potential-quiescent human mesenchymal stem cells is under the reversible control of interferon alpha/beta.

Leukemia·2007

Same author

High pressure fourier transform infrared spectroscopy of poly(dA)poly(dT), poly(dA) and poly(dT).

Biophysical chemistry·2006

Same author

Direct signal transduction via functional interferon-alphabeta receptors in CD34+ hematopoietic stem cells.

Leukemia·2002

Same journal

Extending the classical sequence-structure-function paradigm through protein dynamics and context-dependent behavior.

FEBS letters·2026

Same journal

α-Synuclein aggregation landscape from phase separation to neurotoxic intermediates.

FEBS letters·2026

Same journal

Modelling stem cell differentiation related processes-A practical overview for biologists.

FEBS letters·2026

Same journal

Overlapping gut microbiome signatures in aging and disease are characterized by enrichment of medication-associated oral microbes in the gut.

FEBS letters·2026

Same journal

Csk binding to integrin β3 is regulated by tyrosine and threonine phosphorylation of β3.

FEBS letters·2026

Same journal

Mixed-class J-domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly.

FEBS letters·2026

See all related articles

Researchers isolated and stabilized interferon-receptor protein complexes in vitro. They identified a specific 230,000 molecular weight complex formed by human interferon binding to cellular receptors.

Area of Science:

Biochemistry
Molecular Biology
Immunology

Background:

Interferons are crucial signaling proteins in the immune system.
Understanding interferon-receptor interactions is key to their therapeutic applications.

Purpose of the Study:

To describe the in vitro extraction and stabilization of interferon-receptor complexes.
To characterize the molecular weight and specificity of these complexes.

Main Methods:

In vitro extraction of protein complexes.
Analysis of molecular weight (Mr 230,000).
Time-course analysis of complex formation.

Main Results:

A homogeneous 230,000 molecular weight complex was extracted at peak receptor binding (30 min).

Related Experiment Videos

Complex formation was specific for human interferon.

A second complex was observed at later times, suggesting interferon transfer.

Conclusions:

Discrete interferon-receptor complexes can be isolated and stabilized in vitro.
The binding dynamics suggest a sequential interaction or transfer of interferon to cellular receptors.