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Related Experiment Videos

Prevention by nifedipine of cold pressor-induced decrease in left ventricular ejection fraction.

S Z Goldhaber, H D White, B L Holman

    Journal of the American College of Cardiology
    |June 1, 1983
    PubMed
    Summary
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    Nifedipine protects against cold-induced ventricular dysfunction in patients with coronary artery disease by preventing a drop in ejection fraction during cold exposure. This medication may help safeguard heart function during cold stress.

    Area of Science:

    • Cardiology
    • Pharmacology

    Background:

    • Cold exposure can negatively impact cardiac function, particularly in patients with coronary artery disease (CAD).
    • Understanding the effects of medications like nifedipine on cold-induced cardiac stress is crucial for patient management.

    Purpose of the Study:

    • To investigate the impact of nifedipine on left ventricular function during cold pressor testing in patients with CAD.
    • To determine if nifedipine can mitigate the adverse effects of cold on the heart.

    Main Methods:

    • Eight patients with documented CAD underwent radionuclide ventriculography.
    • Measurements were taken at baseline and during cold pressor tests, both before and after buccal administration of nifedipine (10 mg).

    Main Results:

    Related Experiment Videos

  • Nifedipine significantly attenuated the increase in systolic blood pressure during cold exposure.
  • The decrease in left ventricular ejection fraction observed during the control cold pressor test was abolished after nifedipine administration.
  • Heart rate-pressure product changes were not significantly different between control and nifedipine conditions.

    • Conclusions:

    • Nifedipine effectively prevents cold-induced decreases in left ventricular ejection fraction in patients with obstructive CAD.
    • Nifedipine may protect against cold-induced left ventricular dysfunction, potentially through vasodilation and afterload reduction.
    • These findings suggest a therapeutic role for nifedipine in managing patients with CAD exposed to cold stimuli.