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Angiotensin-converting enzyme activity in postmortem human tissues.

J Lieberman, A Sastre

    Laboratory Investigation; a Journal of Technical Methods and Pathology
    |June 1, 1983
    PubMed
    Summary
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    Human tissues exhibit varying levels of angiotensin-converting enzyme (ACE). This enzyme

    Area of Science:

    • Biochemistry
    • Physiology
    • Enzymology

    Background:

    • Angiotensin-converting enzyme (ACE) plays a crucial role in the renin-angiotensin system.
    • Understanding tissue-specific ACE distribution is vital for physiological and pathological insights.

    Purpose of the Study:

    • To quantify and compare angiotensin-converting enzyme (ACE) activity across diverse human postmortem tissues and pancreatic juice.
    • To investigate the potential physiological roles of ACE in various human organs.

    Main Methods:

    • Spectrophotometric assay of ACE activity using hippuryl-histidyl-leucine substrate.
    • Analysis of postmortem human tissues and pancreatic juice samples.
    • Characterization of enzyme properties including molecular weight and inhibitor sensitivity.

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    Main Results:

    • Significant variations in ACE activity were observed across human tissues, with kidney, ileum, duodenum, and uterus showing high levels.
    • ACE activity generally increased along the small intestine from the pylorus.
    • A distinct carboxypeptidase A-like activity was identified in pancreatic juice, differing from ACE.

    Conclusions:

    • Human tissues display differential ACE expression, suggesting specialized functions.
    • ACE may contribute to digestive or detoxifying processes in the small intestine and kidney.
    • ACE's role in angiotensin I activation is confirmed, alongside potential local tissue functions.