Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Vitamin D metabolism, regulation, function].

R Willvonseder

    Padiatrie Und Padologie
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    This review details vitamin D metabolism, highlighting its absorption, skin production, and liver/kidney hydroxylation to form active metabolites. These compounds regulate calcium and phosphorus homeostasis, crucial for bone mineralization.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Immunology and aging.

    The aging male : the official journal of the International Society for the Study of the Aging Male·2006
    Same author

    Serum levels of osteoprotegerin increase with age in a healthy adult population.

    Bone·2003
    Same author

    Assessment of vitamin D and calcium status in healthy adult Austrians.

    European journal of clinical investigation·2003
    Same author

    Normative data of bone mineral density in an unselected adult Austrian population.

    European journal of clinical investigation·2003
    Same author

    [The prevention of osteoporosis].

    Deutsche medizinische Wochenschrift (1946)·2001
    Same author

    Bone turnover markers and sex hormones in men with idiopathic osteoporosis.

    European journal of clinical investigation·2001
    Same journal

    [Is the Supply of Medicines in Danger?]

    Padiatrie und Padologie·2023
    Same journal

    Padiatrie und Padologie·2023
    Same journal

    Padiatrie und Padologie·2023
    Same journal

    Padiatrie und Padologie·2023
    Same journal

    Padiatrie und Padologie·2023
    Same journal

    Padiatrie und Padologie·2023
    See all related articles

    Area of Science:

    • Endocrinology
    • Nutritional Science
    • Molecular Biology

    Context:

    • Vitamin D is essential for calcium and phosphate homeostasis.
    • Its metabolism involves absorption, skin synthesis, and sequential hydroxylation in the liver and kidneys.
    • Active vitamin D metabolites bind to specific receptors to regulate mineral handling.

    Purpose:

    • To review the metabolism, regulation, and function of vitamin D and its active metabolites.
    • To elucidate the physiological roles of vitamin D in maintaining mineral balance.
    • To highlight the importance of vitamin D during periods of high demand like puberty and perinatal stages.

    Summary:

    • Vitamin D is absorbed and synthesized in the skin, then hydroxylated in the liver to 25-hydroxy-vitamin-D.

    Related Experiment Videos

  • Further hydroxylation in the kidney produces the potent 1,25-dihydroxy-vitamin-D.
  • This active form regulates intestinal, renal, and bone calcium and phosphorus transport, ensuring proper mineralization.

    • Impact:

    • Understanding vitamin D metabolism is critical for managing mineral imbalances and bone health.
    • This review provides insights into the hormonal regulation of calcium and phosphate.
    • Highlights the increased requirement for active vitamin D during rapid growth and development.