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Related Experiment Videos

Croup: an 11-year study in a pediatric practice.

F W Denny, T F Murphy, W A Clyde

    Pediatrics
    |June 1, 1983
    PubMed
    Summary

    Parainfluenza viruses, particularly type 1, are the primary cause of croup in children, with incidence peaking in the second year of life. This study details croup etiology and epidemiology in pediatric lower respiratory tract infections.

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    Area of Science:

    • Pediatric Infectious Diseases
    • Epidemiology
    • Virology

    Background:

    • Croup is a common childhood respiratory illness.
    • Understanding its causes and patterns is crucial for clinical management.
    • Previous studies have identified various viral agents but comprehensive epidemiological data is needed.

    Purpose of the Study:

    • To investigate the etiology and epidemiology of croup in a pediatric population.
    • To determine the incidence and attack rates of croup.
    • To identify the specific infectious agents responsible for croup and their age-specific roles.

    Main Methods:

    • Retrospective study of 951 croup cases within 6,165 lower respiratory tract infections (LRIs) over 11 years (1964-1975).
    • Calculation of attack rates using available census data.
    • Isolation and identification of causative agents from respiratory secretions.

    Main Results:

    • Parainfluenza viruses accounted for 74.2% of identified agents, with type 1 being most prevalent.
    • Croup incidence was highest in the second year of life, with boys more affected than girls.
    • Etiology varied by age: parainfluenza viruses were dominant overall, RSV in younger children (<5 years), and influenza viruses/Mycoplasma pneumoniae in older children (>5-6 years).
    • Croup predominantly occurred in late fall and early winter, coinciding with parainfluenza virus seasonality.

    Conclusions:

    • Parainfluenza viruses are the leading cause of croup across all pediatric age groups.
    • The specific viral etiology of croup is age-dependent.
    • The distinct epidemiology of croup compared to other LRIs aids clinical differentiation.

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