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Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor
Abstract:
The transforming protein of a primate sarcoma virus and a platelet-derived growth factor are derived from the same or closely related cellular genes. This conclusion is based on the demonstration of extensive sequence similarity between the transforming protein derived from the simian sarcoma virus onc gene, v-sis, and a human platelet-derived growth factor. The mechanism by which v-sis transforms cells could involve the constitutive expression of a protein with functions similar or identical to those of a factor active transiently during normal cell growth.
Insights
The simian sarcoma virus oncogene protein (v-sis) shares extensive sequence similarity with human platelet-derived growth factor. This suggests they originate from closely related cellular genes, potentially explaining viral transformation mechanisms.
Area of Science:
- Molecular biology
- Virology
- Cellular biology
Background:
- Cellular genes encode proteins crucial for normal cell growth and function.
- Viral oncogenes can drive uncontrolled cell proliferation, leading to cancer.
Purpose of the Study:
- To investigate the relationship between the simian sarcoma virus transforming protein (v-sis) and platelet-derived growth factor.
- To elucidate the potential mechanism of viral oncogenesis involving v-sis.
Main Methods:
- Sequence analysis to compare the v-sis protein with human platelet-derived growth factor.
- Comparative genomics to identify shared genetic origins.
Main Results:
- Demonstrated extensive sequence similarity between v-sis and human platelet-derived growth factor.
- Identified that v-sis and platelet-derived growth factor likely derive from the same or closely related cellular genes.
Conclusions:
- The transforming protein of simian sarcoma virus (v-sis) is closely related to platelet-derived growth factor.
- Constitutive expression of v-sis may mimic the function of growth factors, leading to cell transformation and potential oncogenesis.