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[Stewart-Treves syndrome. 2 cases with an ultrastructural study]
La Semaine Des Hopitaux : Organe Fonde Par L'Association D'Enseignement Medical Des Hopitaux De Paris
|March 10, 1983
Summary
This ultrastructural study of Stewart-Treves syndrome in elderly women suggests an angiosarcomatous origin for these vascular lesions. Findings reveal distinct cellular and vascular features aiding in diagnosis.
Area of Science:
- Dermatopathology
- Oncology
- Ultrastructural Pathology
Background:
- Stewart-Treves syndrome is a rare complication of chronic lymphedema, often associated with angiosarcoma.
- This study investigates the ultrastructural characteristics of two cases to better understand lesion origins.
Observation:
- Light microscopy revealed vascular features in dermal and hypodermal proliferations.
- Ultrastructural analysis in the first case showed erythrocyte-filled clefts surrounded by neoplastic cells with zonulae adherentes and a rudimentary basal membrane.
- The second case exhibited typical capillary vessels with endothelial cells, pinocytotic vesicles, microfilaments, and zonulae adherentes, featuring a defined membrane with pericytes and anastomotic networks.
Findings:
- The ultrastructural morphology in both cases, particularly the vascular and cellular features, supports an angiosarcomatous origin.
- Distinct differences in the clarity of vascular features were observed between the two cases under light microscopy.
Implications:
- Ultrastructural examination is crucial for diagnosing Stewart-Treves syndrome and differentiating it from other vascular lesions.
- These findings contribute to the understanding of the histogenesis of Stewart-Treves syndrome, aiding in clinical management and further research.