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[Gilles de la Tourette's disease]
La Semaine Des Hopitaux : Organe Fonde Par L'Association D'Enseignement Medical Des Hopitaux De Paris
|March 10, 1983
Summary
Tiapride effectively treated a seventeen-year-old girl with severe Gilles de la Tourette syndrome when other medications failed. Oral or intramuscular tiapride rapidly resolved hyperkinesia and phonatory tics, enabling a near-normal life.
Area of Science:
- Neurology
- Pharmacology
Background:
- Gilles de la Tourette syndrome is a neurological disorder characterized by involuntary motor and phonic tics.
- Typical therapeutic agents often provide limited relief for severe cases.
Observation:
- A seventeen-year-old female presented with a three-year history of particularly disabling typical Gilles de la Tourette syndrome.
- Previous treatments including benzodiazepines, clomethiazole, paraldehyde, and choline chloride were ineffective or only partially effective.
Findings:
- Intramuscular administration of 300 mg/day of tiapride resulted in rapid resolution of hyperkinesia and phonatory tics.
- Conversion to 900 mg/day of oral tiapride maintained the improvement, allowing the patient to resume a nearly normal life.
Implications:
- Tiapride demonstrates significant efficacy in managing severe, treatment-resistant Gilles de la Tourette syndrome.
- This case highlights tiapride as a potential therapeutic option for patients with disabling tic disorders.