[Cervical condyloma and dysplasia: histological and virological correlation apropos of 100 cases]

Colposcopy and cytology have pointed at the frequency of cervical condylomas with special consideration to flat types. The association condyloma/dysplasia and the behavior of carcinomas in situ as sexually transmitted diseases, suggest that human papillomavirus (H. P. V.) could play a role in cervical cancer. 100 patients have undergone examination for coloscopy, cytology, histology and virology. Dysplastic features were observed in 47 p. 100 and led to classify the lesions in 3 groups according to their importance: condylomas (53 p. 100), dysplastic condylomas (25 p. 100) with predominance of condylomatous pattern, dysplasia (22 p. 100) with a predominant dysplastic pattern. Virologic data were correlated with this classification and demonstrate a dramatic relationship between viral disappearance and the presence of dysplastic features. Virus was found in 83 p. 100 of pure condylomas, 16 p. 100 of dysplastic condylomas and 0 p. 100 of condylomatous dysplasias. Such a phenomenon of viral absence is observed in animal models (malignant transformation of Shope's papilloma): this could be a new argument to suspect the carcinogenic potential of H. P. V. for cervix and external genitalia.