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Partial myeloperoxidase deficiency in preleukemia.

P Cech, M Markert, L H Perrin

    Blut
    |July 1, 1983
    PubMed
    Summary
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    This study investigated myeloperoxidase (MPO) deficiency in patients with preleukemia, diabetes, and cancer. Reduced serum opsonic activity was observed, potentially explaining increased bacterial infection susceptibility in preleukemia.

    Area of Science:

    • Immunology
    • Hematology
    • Cell Biology

    Background:

    • Myeloperoxidase (MPO) deficiency is a condition affecting neutrophil function.
    • Patients with preleukemia, diabetes mellitus, and breast cancer can exhibit acquired MPO deficiency.
    • Neutrophil dysfunction can lead to increased susceptibility to bacterial infections.

    Purpose of the Study:

    • To investigate the functional properties of neutrophils (PMNs) in subjects with partial, acquired MPO deficiency.
    • To explore the role of serum opsonic activity in MPO-deficient patients, particularly those with preleukemia.
    • To determine if MPO deficiency impacts intracellular bactericidal activity against Staphylococcus aureus.

    Main Methods:

    • Studied functional properties of neutrophils (PMNs) in seven subjects with partial MPO deficiency.

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  • Assessed intracellular bactericidal activity, oxygen consumption, and superoxide radical production.
  • Evaluated serum opsonic activity in autologous and normal serum systems, and with normal PMNs.

    • Main Results:

    • Intracellular bactericidal activity, oxygen consumption, and superoxide production were normal.
    • Three preleukemia patients showed markedly reduced serum opsonic activity in autologous systems.
    • This reduced opsonic activity was also observed with normal PMNs, suggesting an unknown opsonin deficiency or inhibitor.

    Conclusions:

    • Partial MPO deficiency does not impair intracellular killing of Staphylococcus aureus by PMNs.
    • Reduced serum opsonic activity in preleukemia patients may contribute to increased bacterial infection susceptibility.
    • Further investigation is needed to identify the cause of decreased opsonic activity (unknown opsonin or inhibitor).