Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Differential radiation response amongst proliferating epithelial cells.

C S Potten, S E Al-Barwari, J Searle

    Cell and Tissue Kinetics
    |March 1, 1978
    PubMed
    Summary

    Tissue irradiation causes cell death, but reproductive death doesn't correlate well with observable cell death. Different epithelial cell populations, possibly stem and differentiated cells, show varying responses to radiation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The E3 ubiquitin ligase HUWE1 is required for KRAS-induced lung cancer.

    Cell death & disease·2026
    Same author

    The PI3K-AKT-mTOR axis persists as a therapeutic dependency in KRAS<sup>G12D</sup>-driven non-small cell lung cancer.

    Molecular cancer·2024
    Same author

    Combined positron emission tomography and contrast enhanced CT (PET/CeCT) is a feasible single investigation in the staging of oesophagogastric cancers: single-centre pilot study experience during the COVID-19 pandemic.

    Annals of the Royal College of Surgeons of England·2023
    Same author

    Medizinische Klinik, Intensivmedizin und Notfallmedizin·2017
    Same author

    [Questionnaire for the utilization of the Emergency Department : Implications for the patient survey].

    Medizinische Klinik, Intensivmedizin und Notfallmedizin·2017
    Same author

    [Exploring Patient Motives to Use Emergency Departments for Non-urgent Conditions: A Qualitative Study].

    Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·2016

    Area of Science:

    • Radiobiology
    • Cell Biology
    • Histology

    Background:

    • Tissue irradiation induces both reproductive cell death and observable histological cell death.
    • A poor correlation exists between these two measures of cell death.
    • Many irradiated cells maintain normal cell cycle and maturation activities, suggesting resistance.

    Purpose of the Study:

    • To investigate the discrepancy between reproductive and histological cell death after tissue irradiation.
    • To identify potential epithelial subpopulations with differential radiosensitivity.

    Main Methods:

    • Analysis of cell death markers following tissue irradiation.
    • Observation of cell cycle and maturation activities post-irradiation.
    • Histological examination of irradiated tissue, particularly the intestine.

    Main Results:

    • A low fraction (<0.1) of histologically observable dead cells was noted.
    • Most observable cell death occurred in the presumptive stem cell region of the intestine.
    • Significant populations of cells exhibited unirradiated behavior despite irradiation exposure.

    Conclusions:

    • The data suggest the presence of distinct epithelial subpopulations with varying radioresponses.
    • Stem cells and differentiated proliferative cells may represent these subpopulations with differing sensitivities to radiation.

    Related Experiment Videos