Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Effect of some phenothiazine derivatives on kidney function].

V V Vorontsov

    Farmakologiia I Toksikologiia
    |May 1, 1975
    PubMed
    Summary

    Chlorathizin and Chlormorphathizin significantly increased urine output in rats and dogs. Other tested drugs showed varied effects, with azaphen having no notable impact on urinary flow.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Functional activity of transposase of Bordetella pertussis IS element in Escherichia coli cells].

    Genetika·2006
    Same author

    [Bvg-negative regulation of repeated sequence transferring in Bordetella pertussis cells].

    Genetika·2006
    Same author

    [Identification of the open reading frame coding transposase of Bordetella pertussis RS-element].

    Molekuliarnaia genetika, mikrobiologiia i virusologiia·2004
    Same author

    [Ultrasonic methods of diagnosis of late complications after reconstructive surgery of the aorta and major arteries of the lower limbs].

    Klinicheskaia meditsina·1992
    Same author

    [The effect of ethacrynic acid on the functions of the gastrointestinal tract].

    Farmakologiia i toksikologiia·1991
    Same author

    [Diagnosis and treatment of impotence of vascular etiology].

    Vestnik khirurgii imeni I. I. Grekova·1990

    Area of Science:

    • Pharmacology
    • Nephrology

    Background:

    • Diuretics and saluretics are crucial in managing fluid balance.
    • Understanding the effects of novel compounds on renal function is essential.

    Purpose of the Study:

    • To evaluate the diuretic and saluretic effects of Chlorathizin and Chlormorphathizin.
    • To investigate the impact of Fluorathizin, imizine, Diprazine, and azaphen on urinary flow in animal models.

    Main Methods:

    • Administered Chlorathizin, Chlormorphathizin, Fluorathizin, imizine, Diprazine, and azaphen to rats and dogs.
    • Monitored urinary output and salinity over 24-hour periods.

    Main Results:

    • Chlorathizin and Chlormorphathizin demonstrated significant diuretic and saluretic activity.
    • Fluorathizin and imizine inhibited urinary flow.
    • Diprazine exhibited species-specific effects, increasing output in dogs but decreasing it in rats.
    • Azaphen, an antidepressant, did not markedly affect urinary flow.

    Conclusions:

    • Chlorathizin and Chlormorphathizin possess potent diuretic and saluretic properties.
    • The tested compounds exhibit diverse effects on renal function, highlighting the need for further investigation into their mechanisms of action.

    Related Experiment Videos