Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metabolic abnormalities in diabetic peripheral nerve: relation to impaired function.

D A Greene

    Metabolism: Clinical and Experimental
    |July 1, 1983
    PubMed
    Summary

    Diabetic peripheral nerve dysfunction may stem from metabolic issues impacting the sodium-potassium ATPase pump. Researchers propose testing this hypothesis using the BB diabetic rat model for human insulin deficiency diabetes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Gymnastics participation is associated with skeletal benefits in the distal forearm: a 6-month study using peripheral Quantitative Computed Tomography.

    Journal of musculoskeletal & neuronal interactions·2013
    Same author

    Bone health of apprentice jockeys using peripheral quantitative computed tomography.

    International journal of sports medicine·2013
    Same author

    Skeletal differences at the ulna and radius between pre-pubertal non-elite female gymnasts and non-gymnasts.

    Journal of musculoskeletal & neuronal interactions·2011
    Same author

    Non-elite gymnastics participation is associated with greater bone strength, muscle size, and function in pre- and early pubertal girls.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2011
    Same author

    Establishment and maintenance of in vitro cultures of human retinal pigment epithelium.

    Methods in molecular medicine·2011
    Same author

    Calcium and vitamin-D supplementation on bone structural properties in peripubertal female identical twins: a randomised controlled trial.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2010

    Area of Science:

    • Neuroscience
    • Endocrinology
    • Metabolic Research

    Background:

    • Diabetic peripheral neuropathy is a common complication of diabetes.
    • Specific metabolic abnormalities in the peripheral nerve are linked to nerve dysfunction.
    • The sodium-potassium ATPase (Na+/K+-ATPase) plays a critical role in nerve function.

    Purpose of the Study:

    • To propose a hypothesis linking metabolic abnormalities in diabetic peripheral nerves to impaired function via Na+/K+-ATPase.
    • To identify a suitable animal model for testing this hypothesis.

    Main Methods:

    • Literature review and hypothesis formulation.
    • Identification of the BB diabetic rat as a well-defined model for human insulin-deficiency diabetes.

    Main Results:

    Related Experiment Videos

    • A clear hypothesis is presented connecting specific metabolic derangements to impaired nerve function.
    • The BB diabetic rat is identified as an appropriate model for experimental validation.

    Conclusions:

    • The proposed hypothesis provides a testable framework for understanding diabetic neuropathy.
    • The BB diabetic rat model offers a robust platform for investigating the role of Na+/K+-ATPase in diabetic nerve dysfunction.