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Updated: Oct 7, 2026

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging
09:05

Assessment of Cardiac Morphological and Functional Changes in Mouse Model of Transverse Aortic Constriction by Echocardiographic Imaging

Published on: June 21, 2016

Comparison between apexcardiographic and angiographic indexes of left ventricular performance in patients with aortic

J Manolas, H P Krayenbuehl

    Circulation
    |April 1, 1978
    PubMed

    Insights

    Systolic upstroke time (SUT) effectively assesses left ventricular (LV) performance in aortic incompetence (AI). This noninvasive measure is superior to other apexcardiogram parameters for evaluating LV function in AI patients.

    Area of Science:

    • Cardiology
    • Biomedical Engineering
    • Physiology

    Background:

    • Chronic aortic incompetence (AI) affects left ventricular (LV) function.
    • Assessing LV performance noninvasively is crucial for managing AI patients.

    Purpose of the Study:

    • To evaluate the diagnostic utility of apexcardiogram (ACG) parameters, specifically systolic upstroke time (SUT), in patients with chronic AI.
    • To compare SUT with other ACG indexes (t-dA/dt, a/H) and their correlation with LV ejection fraction (EF) and pressure-derived contractile indexes.

    Main Methods:

    • Simultaneous recording of LV apexcardiogram (ACG) and LV pressure using a tipmanometer in 34 AI patients.
    • Measurement of SUT, time to peak dA/dt (t-dA/dt), and a wave percentage amplitude (a/H) from ACG.
    • Correlation analysis of ACG parameters with LV ejection fraction (EF) and LV pressure-derived indexes.

    Main Results:

    • SUT was significantly prolonged in AI patients with decreased EF (142 ± 19 msec) compared to those with normal EF (99 ± 17 msec).
    • SUT showed a strong correlation with EF (r = 0.85).
    • Other ACG indexes (t-dA/dt, a/H) did not significantly differ between groups and showed weaker correlations with pressure-derived parameters.

    Conclusions:

    • Systolic upstroke time (SUT) is a superior apexcardiographic parameter for assessing left ventricular (LV) performance in chronic aortic incompetence (AI).
    • SUT provides a valuable noninvasive method for evaluating LV function in AI patients, particularly in relation to ejection fraction.

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