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Serum estriol level during treatment with pivmecillinam
Acta Obstetricia Et Gynecologica Scandinavica
|January 1, 1983
Summary
Asymptomatic bacteriuria in pregnant women requires treatment to prevent pyelonephritis. Pivmecillinam/mecillinam is a safe and effective antibiotic option for urinary tract infections in late pregnancy, as it does not affect estriol levels.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Pharmacology
Background:
- Asymptomatic bacteriuria in pregnant women necessitates treatment due to the risk of acute pyelonephritis.
- Certain antibiotics can lower serum estriol levels, posing risks during the last trimester of pregnancy.
Purpose of the Study:
- To evaluate pivmecillinam/mecillinam as a treatment for urinary tract infections (UTIs) in pregnant women, particularly in the last trimester.
- To determine if mecillinam affects serum estriol levels.
Main Methods:
- The study focused on the efficacy of mecillinam against Escherichia coli, a common UTI pathogen in pregnancy.
- Assessment of mecillinam's impact on serum estriol levels was a key component.
Main Results:
- Mecillinam demonstrated effectiveness against Escherichia coli, the predominant pathogen in pregnancy-related cystitis.
- Pivmecillinam/mecillinam was found not to reduce serum estriol levels.
Conclusions:
- Pivmecillinam/mecillinam is a suitable alternative for treating symptomatic and asymptomatic UTIs in pregnant women during the last trimester.
- This antibiotic offers a safe therapeutic option by not interfering with crucial hormonal levels.