Biochemical mechanisms that contribute to alcohol-induced hypogonadism in the male

The above review has presented most if not all of the available evidence supporting a role for alcohol and acetaldehyde as putative environmental Leydig cell toxins for man and animals. Despite a considerable data base and much progress, particularly in the last decade, much yet remains to be learned concerning this phenomenon. It is hoped that this review, and this symposium, will contribute to future progress in this area by providing a basis for new and provocative observations and hypotheses to be tested by a new generation of clinical investigators.