DNA binding proteins induced by varicella-zoster virus in human cells

DNA-binding proteins induced by varicella-zoster virus (VZV) were detected by native-and denatured-DNA affinity chromatography. Eleven DNA-binding proteins specific to the infected cells were separated by SDS polyacrylamide gel electrophoresis (PAGE); their molecular weights ranged from 180 X 10(3) to 22 X 10(3). When they were applied to an affinity column coupled with VZV-antibody, a polypeptide with a molecular weight of 34 X 10(3) was predominant on subsequent SDS-PAGE.