Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modulation of polymorphonuclear leukocyte function by cetiedil.

J B Wolach, T D Coates, D Y Tzeng

    Blood
    |August 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Infection in childhood cancer: experience in management of infection in acute leukemia*.

    Pediatric annals·2014
    Same author

    Philip Sunshine tribute.

    Journal of perinatology : official journal of the California Perinatal Association·2011
    Same author

    Congenital neutropenia in a newborn.

    Journal of perinatology : official journal of the California Perinatal Association·2011
    Same author

    Abnormal autonomic cardiac response to transient hypoxia in sickle cell anemia.

    Physiological measurement·2008
    Same author

    Multisite microelectrode arrays for measurements of multiple neurochemicals.

    Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
    Same author

    Stem cell transplantation in patients with severe congenital neutropenia with evidence of leukemic transformation.

    Bone marrow transplantation·2005
    Same journal

    Fibrocytes drive JAK2V617F-mutated myelofibrosis: pitavastatin reverses marrow fibrosis and anemia.

    Blood·2026
    Same journal

    Identifying steroid-refractory aGVHD before it happens.

    Blood·2026
    Same journal

    ELISA-negative HIT: antibody recognition and relevance.

    Blood·2026
    Same journal

    EBV and immunodeficiency: the odd couple drawn to the brain.

    Blood·2026
    Same journal

    A bone to pick with ferric carboxymaltose.

    Blood·2026
    Same journal

    A step toward streamlining HIT diagnosis.

    Blood·2026
    See all related articles

    Cetiedil citrate monohydrate inhibits polymorphonuclear leukocyte (PMN) aggregation and superoxide release, potentially modulating inflammatory responses. This drug affects PMN function more than degranulation, showing promise for in vivo applications.

    Area of Science:

    • Immunology
    • Pharmacology

    Background:

    • Cetiedil citrate monohydrate is known to inhibit red blood cell sickling and platelet aggregation.
    • Polymorphonuclear leukocytes (PMNs) play a crucial role in inflammatory responses.

    Purpose of the Study:

    • To investigate the effect of cetiedil citrate monohydrate on polymorphonuclear leukocyte (PMN) function.
    • To determine if cetiedil can attenuate PMN activation and inflammatory mediator release.

    Main Methods:

    • Dose-dependent inhibition of PMN aggregation induced by formyl-met-leu-phe (FMLP), phorbol myristate acetate (PMA), and A23187 was assessed.
    • Calcium translocation, superoxide release, receptor availability, and degranulation markers (myeloperoxidase, lactoferrin) were measured.

    Main Results:

    Related Experiment Videos

    • Cetiedil inhibited PMN aggregation in a dose-dependent manner.
    • It reduced calcium translocation, superoxide release, and FMLP receptor availability.
    • The drug showed minimal effect on primary and specific granule release, indicating less impact on degranulation.

    Conclusions:

    • Cetiedil citrate monohydrate significantly affects PMN aggregation and superoxide release.
    • Its limited impact on degranulation suggests a potential role in modulating inflammatory responses in vivo.