Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Synarchic regulation and sensitivity modulation in hormone action.

H Rasmussen

    Bulletin Der Schweizerischen Akademie Der Medizinischen Wissenschaften
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A Randomized Study on the Effect of Dried Fruit on Acid-Base Balance, Diet Quality, and Markers of Musculoskeletal Health in Community Dwelling Adults.

    Journal of the American Nutrition Association·2022
    Same author

    [Onychomadesis in an immunocompetent adult patient].

    Semergen·2017
    Same author

    Selective attention and mismatch negativity in antipsychotic-naïve, first-episode schizophrenia patients before and after 6 months of antipsychotic monotherapy.

    Psychological medicine·2017
    Same author

    Pectic polysaccharides isolated from Malian medicinal plants protect against Streptococcus pneumoniae in a mouse pneumococcal infection model.

    Scandinavian journal of immunology·2013
    Same author

    The influence of impaired processing speed on cognition in first-episode antipsychotic-naïve schizophrenic patients.

    European psychiatry : the journal of the Association of European Psychiatrists·2012
    Same author

    Importance of woody debris in seed germination of Tipularia discolor (Orchidaceae).

    American journal of botany·2011
    Same journal

    About the adrenergic functions on the heart and vessels.

    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften·2010
    Same journal

    Subcutaneous depetoxycorticosterone acetate deposit in a case of adrenal insufficiency.

    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften·2010
    Same journal

    Family osteogenesis imperfecta (type Vrolik) and its treatment with vitamin D shock.

    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften·2010
    Same journal

    Verification of the law of projection of the electrical potentials of the heart on the surface of the human body.

    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften·2010
    Same journal

    About the osmotic mechanism of the plant cell.

    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften·2010
    Same journal

    From the higher centers of the vegetative function system.

    Bulletin der Schweizerischen Akademie der Medizinischen Wissenschaften·2010
    See all related articles

    Calcium ions (Ca2+) and cyclic AMP (cAMP) act as interrelated second messengers in cells. These signaling molecules, termed synarchic regulation, coordinate cellular functions like contraction and secretion.

    Area of Science:

    • Cellular Biology
    • Molecular Signaling

    Background:

    • Extracellular messengers, such as hormones and neurotransmitters, trigger cellular responses via surface receptors.
    • Intracellular calcium ions (Ca2+) and cyclic adenosine monophosphate (cAMP) are key second messengers involved in cellular communication.

    Purpose of the Study:

    • To analyze the relationship between intracellular Ca2+ and cAMP.
    • To propose the concept of 'synarchic regulation' where Ca2+ and cAMP act as interrelated second messengers.
    • To describe variations in Ca2+-cAMP interaction patterns across different cell types.

    Main Methods:

    • Analysis of experimental data on intracellular Ca2+ and cAMP relationships.
    • Characterization of cellular activation pathways involving second messengers.
    • Examination of molecular mechanisms of amplitude and sensitivity modulation in cellular signaling.

    Related Experiment Videos

    Main Results:

    • Ca2+ and cAMP function as interrelated second messengers, collectively regulating cellular functions.
    • Five distinct patterns of Ca2+-cAMP interaction exist: coordinate, hierarchical, redundant, antagonistic, and sequential.
    • Cellular activation involves second messenger concentration changes, receptor binding, and subsequent interactions with response elements.
    • Sensitivity modulation, often mediated by cAMP-dependent phosphorylation of calmodulin-regulated elements, provides molecular support for synarchic regulation.

    Conclusions:

    • Ca2+ and cAMP are crucial, interrelated second messengers governing differentiated cell functions.
    • The concept of synarchic regulation explains the coordinated action of Ca2+ and cAMP.
    • Understanding Ca2+-cAMP interactions and modulation mechanisms is key to deciphering cellular information transfer and response.