Human papilloma virus in multifocal, invasive female genital tract malignancy

Two young patients with multifocal, invasive, verrucoid carcinomas of the lower genital tract are described. Viral particles consistent with human papilloma virus were demonstrated by transmission electron microscopy in areas of koilocytotic malignant and nonmalignant epithelium, and both patients had evidence of impaired immune function. The role of human papilloma virus in genital neoplasia is discussed.