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[Oncogene expression and cell transformation].

S Kawai

    Gan to Kagaku Ryoho. Cancer & Chemotherapy
    |February 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Viral oncogenes (v-onc) originate from cellular proto-oncogenes (c-onc) in normal cells. Aberrant expression of these genes can lead to cancer, with avian sarcoma viruses offering insights into this mechanism.

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    Area of Science:

    • Molecular biology
    • Genetics
    • Oncology

    Context:

    • Retroviral transforming genes (v-onc) are derived from cellular proto-oncogenes (c-onc).
    • Proto-oncogenes have essential roles in normal cell proliferation and differentiation.
    • Abnormal expression of oncogenes is a proposed mechanism for carcinogenesis.

    Purpose:

    • To describe common features of avian sarcoma virus (ASV) oncogene products and their cellular counterparts.
    • To present experimental evidence on the relationship between viral and cellular oncogenes.
    • To explore the mechanism of cell transformation mediated by viral oncogene products.

    Summary:

    • Viral oncogenes (v-onc) share common features with cellular proto-oncogenes (c-onc).
    • Experiments with recovered ASV indicate a close relationship between viral and cellular oncogenes.

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  • Studies investigate how viral oncogene products induce cell transformation.

    • Impact:

    • Elucidates the origin and function of oncogenes in cancer development.
    • Provides a foundation for understanding viral carcinogenesis.
    • Offers insights into the molecular mechanisms underlying cell transformation.