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Related Experiment Videos

Evaluation of ketoconazole.

C A Sohn

    Clinical Pharmacy
    |May 1, 1982
    PubMed
    Summary

    Ketoconazole is an oral antifungal drug that works by inhibiting ergosterol synthesis in fungi. While effective for various fungal infections, more large-scale studies are needed to fully assess its long-term safety and efficacy.

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    Area of Science:

    • Pharmacology
    • Mycology
    • Pharmacokinetics

    Background:

    • Ketoconazole is a novel imidazole derivative with oral antifungal activity.
    • It functions by disrupting ergosterol synthesis, a critical component of fungal cell membranes.

    Purpose of the Study:

    • To review the pharmacology, microbiology, pharmacokinetics, clinical applications, adverse effects, and drug interactions of ketoconazole.
    • To evaluate the efficacy and safety profile of this new antifungal agent.

    Main Methods:

    • Review of existing literature on ketoconazole.
    • Analysis of pharmacokinetic data including absorption, distribution, metabolism, and excretion.
    • Compilation of clinical data on approved and potential uses, as well as adverse effects.

    Main Results:

    • Ketoconazole is absorbed from the GI tract, with absorption influenced by gastric pH.
    • It distributes widely in the body and is eliminated biphasically.
    • Approved for treating various fungal infections like candidiasis and histoplasmosis; shows promise for others.

    Conclusions:

    • Ketoconazole is a promising oral antifungal agent effective against a range of fungi.
    • Common side effects include nausea and vomiting; transient liver enzyme elevations can occur.
    • Further large-scale comparative studies are required to establish definitive efficacy and long-term safety.

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