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Anthralin: historical and current perspectives.

R E Ashton, P Andre, N J Lowe

    Journal of the American Academy of Dermatology
    |August 1, 1983
    PubMed
    Summary
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    Anthralin, a psoriasis treatment since 1916, is effective but underused due to side effects. Improved patient and physician education could increase its application for psoriasis management.

    Area of Science:

    • Dermatology
    • Pharmacology

    Background:

    • Anthralin, synthesized in 1916, is a topical agent for psoriasis treatment.
    • Its precursor, chrysarobin, is a natural product derived from the araroba tree.

    Observation:

    • Anthralin use has been limited, particularly in the US, due to skin staining and irritation.
    • Strategies like low concentration, short contact therapy, and steroid co-administration show limited success in mitigating side effects.

    Findings:

    • Anthralin's mechanism of action is believed to involve deoxyribonucleic acid (DNA) interaction, reducing cell turnover.
    • It may also affect enzyme systems, including those in polyamine synthesis and respiration.

    Implications:

    • Enhanced patient and physician education may promote wider adoption of anthralin for psoriasis.

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  • Further research into optimizing anthralin's formulation and application could improve its therapeutic index.