Pupillography response to methadone challenge: aid to diagnosis of opioid dependence

Diagnostic pupillography, under blind conditions, produced constrictions greater than 0.75 mm in 25 opiod addicts and no change or dilation in 82 others. Placebo use produced no constrictions in 99 subjects. Methadone test dose pupillography provides significant information useful in diagnosing opioid dependence and is more acceptable to addicts than naloxone testing.