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Updated: Aug 19, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
09:43

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection

Published on: March 30, 2018

[The spectrum of infections caused by the Epstein-Barr virus]

M P Glauser

    Schweizerische Medizinische Wochenschrift
    |July 2, 1983
    PubMed

    Insights

    Epstein-Barr virus (EBV) infects B lymphocytes, potentially causing uncontrolled proliferation. Immune responses control EBV, but immunodeficiency can lead to severe illness or cancers like lymphoma.

    Area of Science:

    • Virology
    • Immunology
    • Oncology

    Context:

    • Epstein-Barr virus (EBV) identified in Burkitt lymphoma cells in 1964.
    • EBV confirmed as the cause of infectious mononucleosis in 1968.
    • EBV specifically targets B lymphocytes, crucial immune cells.

    Purpose:

    • To elucidate the pathogenic mechanisms of Epstein-Barr virus (EBV) infection.
    • To understand the interplay between EBV, B lymphocytes, and T lymphocytes.
    • To explore EBV's role in various clinical manifestations, including infectious mononucleosis and lymphomas.

    Summary:

    • EBV infects B lymphocytes, inducing uncontrolled proliferation if the immune system cannot control it.
    • T lymphocytes combat EBV-infected cells, with stimulated T cells appearing as 'atypical lymphocytes' during acute infectious mononucleosis.
    • Immunodeficiency compromises cell-mediated immunity, increasing risks of lethal infectious mononucleosis or B cell lymphomas.

    Impact:

    • Highlights the critical role of cell-mediated immunity in controlling EBV.
    • Explains the link between EBV, immunosuppression, and lymphomagenesis in transplant patients.
    • Underscores the diverse geographic and clinical outcomes of EBV infection, from asymptomatic cases to specific cancers.

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