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Related Experiment Videos

Cefmenoxime penetration into gallbladder bile and tissue.

B R Smith, J LeFrock, B B Carr

    Antimicrobial Agents and Chemotherapy
    |June 1, 1983
    PubMed
    Summary

    Cefmenoxime antibiotic concentrations in gallbladder bile and tissue were measured after intravenous administration. Therapeutic levels were achieved, indicating effectiveness in biliary tract infections.

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    Area of Science:

    • Pharmacology
    • Surgical Infection Prophylaxis

    Background:

    • Cefmenoxime is a third-generation cephalosporin antibiotic.
    • Assessing antibiotic concentrations in surgical sites is crucial for effective treatment.

    Purpose of the Study:

    • To determine cefmenoxime concentrations in gallbladder bile and tissue.
    • To evaluate the dose and time dependency of biliary tree penetration.
    • To confirm achievement of therapeutic concentrations.

    Main Methods:

    • Patients undergoing cholecystectomy received intravenous cefmenoxime (0.5g or 1.0g).
    • Bile and tissue samples were collected at various time points post-administration.
    • Drug concentrations were quantified using appropriate analytical methods.

    Main Results:

    • Mean bile concentrations ranged from 54.1 to 169.7 µg/ml depending on dose and time.
    • Mean tissue concentrations ranged from 6.1 to 17.9 µg/g.
    • Biliary penetration demonstrated a clear dose and time-dependent relationship.

    Conclusions:

    • Intravenous cefmenoxime achieves therapeutic concentrations in gallbladder bile and tissue.
    • The antibiotic's penetration into the biliary tree is influenced by dosage and time.
    • Cefmenoxime shows potential for treating biliary tract infections.

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