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Related Experiment Videos

Age-dependent decrease of beta-adrenoceptor density in the submandibular glands of mice and its modulation by the

P Fattoretti, C Viticchi, L Piantanelli

    Archives of Gerontology and Geriatrics
    |November 1, 1982
    PubMed
    Summary

    Aging decreases beta-adrenergic receptor density in mouse submandibular glands. Thymus grafting partially reversed this age-related decline, suggesting hormonal involvement in receptor regulation.

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    Area of Science:

    • Endocrinology
    • Gerontology
    • Molecular Biology

    Background:

    • Beta-adrenergic receptors play a crucial role in regulating physiological functions, including salivary gland secretion.
    • Age-related changes in receptor density can impact tissue responsiveness and overall function.
    • The thymus is known to influence immune and endocrine functions, potentially affecting aging processes.

    Purpose of the Study:

    • To investigate the impact of aging on beta-adrenergic receptor characteristics in mouse submandibular glands.
    • To determine if neonatal thymus grafting can ameliorate age-related changes in these receptors.
    • To explore the potential role of hormonal factors in the regulation of beta-adrenergic receptor density during aging.

    Main Methods:

    • Characterization of beta-adrenergic receptors in submandibular glands from young, aged, and thymus-grafted old mice.

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  • Quantification of receptor affinity and density using radioligand binding assays.
  • Statistical analysis to compare receptor parameters between different animal groups.

    • Main Results:

    • No significant changes in beta-adrenergic receptor affinity were observed with age or thymus grafting.
    • A progressive decrease in receptor density was found in aging mice.
    • Thymus-grafted old mice exhibited a significant recovery of receptor density compared to untreated aged mice.

    Conclusions:

    • Age-related decline in submandibular gland beta-adrenergic receptor density is a key factor in impaired responsiveness.
    • Neonatal thymus grafting can partially restore receptor density, suggesting a thymus-mediated regulatory mechanism.
    • Hormonal factors, particularly thyroid hormones, are implicated in the age- and thymus-dependent regulation of beta-adrenergic receptors.