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Evolutionary relationships between papovaviruses and their hosts.

S Scherneck, J Feunteun, F Vogel

    Archiv Fur Geschwulstforschung
    |January 1, 1983
    PubMed
    Summary

    Researchers characterized the Syrian hamster papovavirus (HaPV) genome, finding extensive homology with polyomaviruses (Py-V) but not papillomaviruses (PV). This suggests HaPV may be more closely related to polyomaviruses despite papilloma-inducing properties.

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    Area of Science:

    • Virology
    • Molecular Biology
    • Genomics

    Background:

    • The Papovaviridae family includes papillomaviruses (PV) and polyomaviruses (Py-V), sharing conserved DNA regions and antigenic determinants.
    • Previous studies suggested evolutionary relationships within PV and Py-V genera, but inter-generic homology remained unconfirmed.
    • The classification of a novel papilloma-producing papovavirus from Syrian hamsters (HaPV) was uncertain due to conflicting biological and molecular characteristics.

    Purpose of the Study:

    • To molecularly characterize the genome of the Syrian hamster papovavirus (HaPV).
    • To determine the genomic homology and evolutionary relationship of HaPV with other papovaviruses.
    • To clarify the taxonomic position of HaPV within the Papovaviridae family.

    Main Methods:

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  • Genome analysis using restriction endonuclease cleavage and binding sites for phage T4 gene 32 protein and E. coli RNA polymerase.
  • Filter hybridization and electron microscopy to assess nucleotide sequence homology under varied stringency conditions.
  • Comparative analysis with human PV types 1 and 4, SV40, Mastomys natalensis PV (MnPV), and polyomavirus (Py).

    • Main Results:

    • HaPV DNA analysis revealed distinct characteristics compared to other known papovaviruses.
    • No significant DNA homology was found between HaPV and human PV types 1 and 4.
    • Extensive DNA homology was detected between HaPV and polyomavirus (Py) under stringent conditions, and with SV40 and MnPV under non-stringent conditions.

    Conclusions:

    • The genomic data suggest HaPV is more closely related to polyomaviruses (Py-V) than to papillomaviruses (PV).
    • HaPV's classification within the Papovaviridae family requires re-evaluation based on its genomic properties.
    • The findings contribute to understanding papovavirus evolution and classification.