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Leukotrienes stimulate acid secretion from isolated gastric parietal cells

R Magous, J P Bali, J C Rossi

Biochemical and Biophysical Research Communications

|August 12, 1983

Abstract:

Leukotrienes LTC4 and LTD4 display contractile effect on the stomach. The stimulation of acid secretion by LTC4, LTD4 and LTE4 was evidenced on a crude isolated cell preparation from rabbit gastric mucosa using the (14C)aminopyrine accumulation method. LTs were in the same order of potency. No potentiation with histamine, carbachol or IBMX was observed suggesting a specific mechanism for LTs on parietal cell.

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