[Effect of antioxidants of the 3-hydroxypyridine class on cyclic 3', 5'-adenosine monophosphate phosphodiesterase activity]

It was shown that derivatives of oxypyridine inhibit activity of 3,5-AMP phosphodiesterase I and II from the rabbit heart. 2-ethyl-6-methyl-3-oxypyridine and proxypheine inhibited 3,5-AMP phosphodiesterase activity in human lymphocytes substantially higher than theophilline widely used in clinical practice.