[Effect of antioxidants of the 3-hydroxypyridine class on cyclic 3', 5'-adenosine monophosphate phosphodiesterase

L D Smirnov, L S Malykhina, V G Lazarevich

Biulleten' Eksperimental'Noi Biologii I Meditsiny

|September 1, 1983

Abstract:

It was shown that derivatives of oxypyridine inhibit activity of 3,5-AMP phosphodiesterase I and II from the rabbit heart. 2-ethyl-6-methyl-3-oxypyridine and proxypheine inhibited 3,5-AMP phosphodiesterase activity in human lymphocytes substantially higher than theophilline widely used in clinical practice.

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Abstract:

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[Effect of antioxidants of the 3-hydroxypyridine class on cyclic 3', 5'-adenosine monophosphate phosphodiesterase