Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pattern reversal visual evoked potentials in awake rats.

W K Boyes, R S Dyer

    Brain Research Bulletin
    |June 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Detection of silver nanoparticles in cells by flow cytometry using light scatter and far-red fluorescence.

    Cytometry. Part A : the journal of the International Society for Analytical Cytology·2013
    Same author

    Detection of TiO2 nanoparticles in cells by flow cytometry.

    Cytometry. Part A : the journal of the International Society for Analytical Cytology·2010
    Same author

    A physiologically based pharmacokinetic model for trichloroethylene in the male long-evans rat.

    Toxicological sciences : an official journal of the Society of Toxicology·2002
    Same author

    A comparison of Haber's rule at different ages using a physiologically based pharmacokinetic (PBPK) model for chloroform in rats.

    Toxicology·2002
    Same author

    Neurotoxic and pharmacokinetic responses to trichloroethylene as a function of exposure scenario.

    Environmental health perspectives·2000
    Same author

    Retinal degeneration in licensed pesticide applicators.

    American journal of industrial medicine·2000
    Same journal

    Expression of concern: "Effect of perioperative preemptive analgesia on hippocampal GABAA receptor α1/α5 balance in aged mild cognitive impairment rats" [Brain Res. Bull. 237 (2026) 111811].

    Brain research bulletin·2026
    Same journal

    Ubiquitination in ischemic stroke: Molecular mechanisms and therapeutic implications.

    Brain research bulletin·2026
    Same journal

    Corrigendum to "Peripheral to central: Exploring the neural, endocrine, and immune pathways of the gut-brain axis in postoperative neurocognitive dysfunction" [Brain Res. Bull. 242 (2026) 111975].

    Brain research bulletin·2026
    Same journal

    GLUT1-driven glycolytic reprogramming in microglia promotes neuroinflammation and cognitive deficits in sepsis-associated encephalopathy.

    Brain research bulletin·2026
    Same journal

    Spinal astrocytes hardly proliferate following peripheral nerve injury: Evidence from adult Aldh1l1-GFP reporter mice.

    Brain research bulletin·2026
    Same journal

    Shared neural mechanisms of trait mindfulness and hypnotic susceptibility: A scoping review toward a unifying predictive coding framework.

    Brain research bulletin·2026
    See all related articles

    A new method records pattern reversal evoked potentials (PREPs) in awake rats, avoiding anesthesia. This technique provides reliable visual acuity data in rodents.

    Area of Science:

    • Neuroscience
    • Ophthalmology
    • Animal Models

    Background:

    • Anesthesia can interfere with neurophysiological recordings in animal models.
    • Previous methods for recording pattern reversal evoked potentials (PREPs) often required anesthesia.
    • Developing an anesthetic-free method is crucial for accurate electrophysiological studies in rats.

    Purpose of the Study:

    • To develop and validate a method for recording PREPs in awake, restrained rats.
    • To establish normative electrophysiological data for visual acuity assessment in rats.
    • To avoid potential confounding effects of anesthesia on neurophysiological measurements.

    Main Methods:

    • Modified Onofrj et al. procedure for awake, restrained rats.
    • Utilized a harness and a pattern-generating TV screen with alternating gratings.

    Related Experiment Videos

  • Recorded waveforms and analyzed peak latencies in hooded and albino rats.

    • Main Results:

    • Successfully recorded reliable PREP waveforms with five identifiable peaks (N1, P1, N2, P2, N3).
    • Established mean peak latencies for hooded rats: N1 (47.3 ms), P1 (65.7 ms), N2 (83.3 ms), P2 (94.4 ms), N3 (129.8 ms).
    • PREP-derived spatial acuity estimates closely matched behavioral measurements in both rat strains.

    Conclusions:

    • The developed method provides a reliable, anesthetic-free approach for assessing visual acuity in rats using PREPs.
    • This technique allows for more accurate neurophysiological studies by eliminating anesthetic interactions.
    • Normative data established can serve as a valuable reference for future research involving rodent visual function.