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Vitamin D-mediated decrease of Ca2+-pump activity in the rat parotid gland.

M Hayakawa, H Aoki, N Terao

    The International Journal of Biochemistry
    |January 1, 1983
    PubMed
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    Vitamin D3 supplementation reduced calcium (Ca2+) uptake and Ca2+-ATPase activity in rat parotid glands. This indicates vitamin D

    Area of Science:

    • Biochemistry
    • Endocrinology
    • Nutritional Science

    Background:

    • Vitamin D is crucial for calcium homeostasis.
    • The role of vitamin D in salivary gland function, specifically parotid glands, is not fully understood.
    • Vitamin D deficiency can impact calcium metabolism.

    Purpose of the Study:

    • To investigate the effect of vitamin D3 administration on calcium (Ca2+) handling in rat parotid glands.
    • To assess in vitro and in vivo Ca2+ uptake and Ca2+-ATPase activity in vitamin D-deficient rats.

    Main Methods:

    • Preparation of microsomes from vitamin D-deficient rat parotid glands.
    • Measurement of in vitro Ca2+-ATPase activity and 45Ca2+ uptake in microsomes.
    • Assessment of in vivo 45Ca2+ uptake in parotid glands following oral vitamin D3 administration.

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    Main Results:

    • Oral vitamin D3 administration significantly decreased in vitro Ca2+-ATPase activity and 45Ca2+ uptake in parotid gland microsomes from vitamin D-deficient rats.
    • A strong parallel decrease was observed between Ca2+-ATPase activity and 45Ca2+ uptake (r = 0.83).
    • In vivo 45Ca2+ uptake in the parotid glands of vitamin D-deficient rats was also reduced by vitamin D3 administration.

    Conclusions:

    • Vitamin D3 plays a role in regulating calcium uptake and transport in rat parotid glands.
    • The findings suggest that vitamin D influences the function of Ca2+-ATPase in salivary glands.
    • Further research is needed to elucidate the precise mechanisms of vitamin D action in parotid gland calcium metabolism.