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Related Experiment Videos

Histamine and the hypothalamus.

F Roberts, C R Calcutt

    Neuroscience
    |August 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Histamine plays a role in the hypothalamus, influencing functions like blood pressure and hormone release. However, more research is needed to fully understand its physiological functions in the brain.

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    Area of Science:

    • Neuroscience
    • Endocrinology
    • Pharmacology

    Background:

    • Histamine is a neurotransmitter found in the brain, with evidence suggesting its presence and activity within the hypothalamus.
    • The hypothalamus is a key brain region regulating numerous physiological functions, including cardiovascular control, appetite, body temperature, and hormone release.

    Purpose of the Study:

    • To review the evidence linking histamine to hypothalamic functions.
    • To assess the presence and roles of histamine receptors (H1 and H2) in the hypothalamus.
    • To evaluate the physiological significance of endogenous histamine in hypothalamic regulation.

    Main Methods:

    • Review of existing literature on histamine distribution, synthesis, and metabolism in the hypothalamus.
    • Analysis of studies using iontophoresis, mepyramine binding, and histamine-stimulated adenylate cyclase assays.

    Related Experiment Videos

  • Examination of the effects of histamine receptor agonists and antagonists administered intracerebroventricularly.
  • Consideration of studies involving enzyme inhibitors and receptor antagonists to infer endogenous histamine roles.

    • Main Results:

    • Histamine and its related enzymes are found in the hypothalamus, consistent with both mast cells and histaminergic nerve terminals.
    • Both histamine H1 and H2 receptors are present in the hypothalamus.
    • Exogenous histamine affects numerous hypothalamic functions, but evidence for endogenous histamine's role is limited to specific functions like TSH and prolactin release, and blood pressure control.
    • Few studies have differentiated effects on pre/postsynaptic receptors or hypothalamic vasculature.

    Conclusions:

    • There is substantial evidence linking histamine to the hypothalamus.
    • Further research using advanced techniques like microinjection and in vitro studies is required to elucidate the precise physiological roles of histamine within the hypothalamus.