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Updated: Aug 10, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

Detection of antibodies to herpes simplex virus with a continuous cell line expressing cloned glycoprotein D

P W Berman, D Dowbenko, L A Lasky

    Science (New York, N.Y.)
    |November 4, 1983
    PubMed

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    Herpes

    Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...